Cissus Quadrangularis Benefits Review 2018

Cissus quadrangularis was originally thought to be traditional medicine from Ayurveda. However it appears to be grown and harvested from a widely dispersed range of locations particularly in Asia and Africa which lend credence to its purported medicinal values.

The herb also goes by the name Asthi Shrinkhala and is considered a grape. Cissus has been discovered to be rich a variety of anti-oxidants such as resveratrol, vitamins C and E, and beta carotene among others.

Newly Discovered Health Benefits of Cissus Quadrangularis

bunch of grapes

The plant is traditionally used to treat conditions associated with women such as menopause, libido and menstrual disorders. Other medicinal benefits include relieving conditions for ulcer and haemorrhoids. But there are lots of newly discovered benefits of the supplement. Here are some of them:

Strengthen Bones and Improve Joint Health

Cissus reportedly can help strengthen bones, improve joint health and may actually rebuild cartilage and collagen which is a protein that repairs damaged fibers. This is why cissus has become a popular supplement for athletes and bodybuilders.

Likewise there are claims that the plant can speed up the healing of bones that have been fractured which is why cissus is often referred to as the “Bone Setter”.

bone x ray

Are these bone and joint strengthening claims warranted?

Unfortunately most of the research done on cissus’ benefits on bones and joints were conducted on rodents and not humans. There are also not enough comprehensive studies done to validate its ability to increase the healing rate of bones that have fractured.

However research has shown cissues might have the ability to accelerate the recovery process of damaged bones by regulating corticosteroid signalling processes and by initiating bone tissue synthesis.

Cissus may have health benefits when taken as a joint and bone health supplement especially for women and athletic adults. But it should be made very clear that the lack of conclusive research may not result in any of its reported benefits.

Promotes Relaxation and Helps Manage Stress

Experiments done on mice show that cissus has the benefit of enhancing the quality of sleep by increasing the levels of GABAA signalling.

stressed woman

GABAA or gamma aminobutyric acid is a neurotransmitter in the Central Nervous System (CNS) which is responsible for reducing neuronal excitability. It is also believed to regulate muscle tone.

Enhanced GABAA levels lead to better relaxation, longer and higher quality of sleep. However, because of its muscle relaxing properties which occur 30 minutes upon ingestion, cissus is not an ideal pre-workout supplement.

Research involving mice given cissus one hour before being induced with epileptic seizures through Isonicotinic Hydrazide Acid (IHA) or electric shock showed reduced frequency of convulsions.

Helps Maintain Healthy Hormone Levels, Preserve Muscle Mass and Encourage Fat Loss

Research has shown cissus might help regulate stress by optimizing the levels of the cortisol and testosterone for both men and women. It may also improve glucose response among healthy individuals. These conditions may lead to a greater preservation of muscle mass while encouraging fat loss.

There are also studies that report cissus can help with weight loss. It should be noted that participants in the study were asked to take cissus, which has gum forming properties, before meals.

Substances with gum forming properties expand when taken with water thereby giving one the feeling of being full and thereby suppress appetite.

Anti-Inflammatory, Anti-Allergy, Anti-Bacterial and Anti-Ulcer Effects

Further studies on lab mice show that cissus contains anti-oxidant compounds that activate HO-1 or heme oxygenase which help suppress inflammation. Research also reveals that cissus has tannin-like structures that inhibit COX or Cyclooxygenase which is responsible for the inflammatory response.

Although some research points to cissus having anti-allergy effects, the results remain inconclusive and ambiguous.

The same should be said about its reported anti-bacterial properties. Despite experiments that show cissus offers some protection against helicobachter pylori infections, the results are not conclusive.

When administered in a rehabilitative or preventive manner, oral doses of cissus at 80 to 160mg/kg may have anti-ulcer properties.

How to Take Cissus Quadrangularis

For the purpose of reducing joint pain, research recommends using 3,200mg of cissus every day. This is the dosage in which current research on animals suggest most effectively maximizes the plant’s sedative and pain killing effects.

But for commercial standardized extracts of cirrus quadragularis, a dosage range of 300 to 600mg with 2.5% ketosteroids appears to generate the best results.

A popular brand of cirrus quadrangularis supplement in the market, Cirrus Quadrangularis by Vitamonk recommends 2,000mg per day.

Athletes and bodybuilders might be better off taking cirrus at the high range of the dosage to maximize its joint support benefits.

Should You Take Cirrus Quandragularis?

Cirrus quadrangularis appears to be a good supplement to take if your purpose is to improve joint health or manage stress levels. These are the benefits which appear to be well-supported by research.

The rest of its reported benefits: fat loss, preservation of muscle mass, faster healing of bone fractures, cardiovascular health, increased libido, anti-allergy, anti-inflammatory, anti-bacterial and anti-ulcer properties do not have enough credible research to back up the claims.

Besides, there has been no discovery of potential side effects with taking cirrus quadrangularis.